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Loading and maintenance: Higher initial doses tapering to maintenance levels

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A classic example is vitamin B12, which may pass through the bloodstream relatively quickly yet persist in liver stores for far longer, supporting normal function between doses

The crude was purified by flash column chromatography on the silica gel (10% EtOAc/Petroleum Ether) to afford the title compound as a white solid (635 mg, 68% yield)

Arch Neurol 2012;69, 836-841